The Obtain: gene-editing HIV, and find out how to destroy PFAS

That is in the present day’s version of The Obtain, our weekday e-newsletter that gives a day by day dose of what’s happening on the planet of expertise.

Three folks had been gene-edited in an effort to treatment their HIV. The result’s unknown.

The information: The gene-editing expertise CRISPR has been used to vary the genes of human infants, to change animals, and to deal with folks with sickle-cell illness. Now scientists are trying a brand new trick: utilizing CRISPR to completely treatment folks of HIV. 

How they did it: A biotechnology firm referred to as Excision BioTherapeutics says it added the gene-editing device to the our bodies of three folks dwelling with HIV and commanded it to chop, and destroy, the virus wherever it’s hiding.

What it means: The early-stage examine is a probing step towards the corporate’s eventual objective of curing HIV an infection with a single intravenous dose of a gene-editing drug. Nonetheless, as a result of the medical doctors withheld early information concerning the remedy’s results, outdoors consultants have been left guessing whether or not it labored. Learn the total story.

—Antonio Regalado

The race to destroy PFAS, the ceaselessly chemical compounds 

What do firefighting foams, mountain climbing boots, raincoats, nonstick frying pans, lipstick, and even ink have in frequent? They will all comprise PFAS, a household of chemical compounds which were utilized in numerous functions for many years. 

The compounds are ubiquitous in consuming water and soil, even migrating to Arctic sea ice. PFAS are referred to as ceaselessly chemical compounds as a result of as soon as current within the surroundings, they don’t degrade or break down. They accumulate, and in the end persist. 

Firms and researchers are actually on a mission to scale back the quantity of PFAS within the surroundings. However destroying PFAS is just one step within the full remediation course of—the last word objective is to get rid of them for good. Learn the total story.  

—John Wiegand

How warmth batteries promise a cleaner future in industrial manufacturing

That is an thrilling week for the heat-battery business. Yesterday, Antora Vitality, a California-based startup, introduced its plan to open its first large-scale manufacturing facility in San Jose. 

Whereas Antora has been producing modular warmth batteries for some time, the corporate says this new manufacturing facility will considerably enhance its manufacturing capability, which has the potential to assist transition heavy industries away from fossil fuels.

June Kim, our editorial fellow, dug into what the announcement means for the manufacturing industries that might find yourself as Antora’s clients, and for the way forward for the heat-battery business as a complete. Learn the total story.

June’s story is from The Spark, MIT Expertise Overview’s weekly local weather and vitality e-newsletter. Join to obtain it in your inbox each Wednesday.

2023 Local weather Tech Firms to Watch: Chic Programs and its clear cement

Chic Programs has invented a brand new option to make cement. The startup’s strategy employs electrochemistry to dramatically reduce emissions, each by tweaking the chemical reactions concerned and by eliminating the necessity for prime temperatures, to reinvent one of many world’s dirtiest supplies. Learn extra concerning the firm, and take a look at the remainder of the checklist of Local weather Tech Firms to Watch.

The must-reads

I’ve combed the web to seek out you in the present day’s most enjoyable/essential/scary/fascinating tales about expertise.

1 The White Home is about to difficulty an AI government order 
It’ll require AI fashions to endure assessments earlier than reaching federal staff. (WP $)
+ It’s designed to pressure AI firms to develop applied sciences extra safely. (WSJ $) 
+ Our fast information to the 6 methods we will regulate AI. (MIT Expertise Overview)

2 Sam Bankman-Fried goes to testify in his fraud trial
He’s dealing with an uphill battle to persuade the jury he acted in good religion. (NYT $)
+ Defendants don’t are inclined to take the stand in fraud trials. (Wired $)

three An antiviral tablet seems to shorten covid’s signs 
However the FDA isn’t satisfied sufficient to approve it for the US. (The Atlantic $)
+ Who advantages most from the brand new covid vaccines? (MIT Expertise Overview)

four Journalists in Gaza are turning to old-school tech
Regardless of the atrocities and unstable web, they’re holding the world up to date. (Wired $)
+ Hamas is broadcasting murders on the victims’ personal social media profiles. (Slate $)
+ Watching the battle unfold on-line is a thankless activity. (Bloomberg $)

5 Sergey Brin’s airship has been authorised for check flights
Hopefully it’ll show to be a lot safer than its predecessors. (IEEE Spectrum)
+ Welcome to the large blimp increase. (MIT Expertise Overview)

6 Utah’s Silicon Slopes has a gender equality drawback
Feminine engineers have been left shocked and traumatized by the conservative state’s startup tradition. (Insider $)
+ Why can’t tech repair its gender drawback? (MIT Expertise Overview)

7 Threads has reached near 100 million month-to-month customers
However are they going to stay round? (The Verge)
+ The social money cow? It’s nonetheless Fb for some creators. (Insider $)

eight Dwelling tissues are surprisingly symmetrical
The discovering may shed some gentle on how tissues transfer—and heal. (Quanta Journal)
+ This mathematician is making sense of nature’s complexity. (MIT Expertise Overview)

9 How AI permeates your day
From very first thing within the morning, to last item at night time. (The Guardian)

10 Apple’s climate app stinks 🌧
It appears to have a major problem with forecasting rain precisely. (Vox)

Quote of the day

“FTX is ok. Belongings are positive.”

—A submit that Sam Bankman-Fried, searching for to guarantee crypto watchers that his firm FTX was in good well being, made on X (previously Twitter) in November final yr, which is more likely to be learn out in courtroom when he testifies in his fraud trial, Reuters studies. 

The large story

How AI helps historians higher perceive our previous

April 2023

Historians have began utilizing machine studying to look at historic paperwork, together with astronomical tables like these produced in Venice and different early fashionable cities.

Proponents declare that the applying of contemporary laptop science to the previous helps draw connections throughout a broader swath of the historic file than would in any other case be attainable, correcting distortions that come from analyzing historical past one doc at a time.

However it introduces distortions of its personal, together with the chance that machine studying will slip bias or outright falsifications into the historic file. Learn the total story.

—Moira Donovan

We are able to nonetheless have good issues

A spot for consolation, enjoyable and distraction in these bizarre occasions. (Acquired any concepts? Drop me a line or tweet ’em at me.)

+ Why can we expertise déjà vu? No actually, why can we expertise déjà vu?
+ Mad Males followers stand up: and revel in a sneak peek inside Don Draper’s New York condo
+ Nostalgic TikToks are the place it’s at.
+ Phew: this runaway tortoise has been delivered to justice after three years on the run.
+ On today 39 years in the past, a sci-fi basic was launched—comfortable anniversary to The Terminator!

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